Lymph stasis promotes tumor growth
نویسندگان
چکیده
منابع مشابه
Hedgehog signaling promotes prostate xenograft tumor growth.
During fetal prostate development, Sonic hedgehog (Shh) expression by the urogenital sinus epithelium activates Gli-1 expression in the adjacent mesenchyme and promotes outgrowth of the nascent ducts. Shh signaling is down-regulated at the conclusion of prostate ductal development. However, a survey of adult human prostate tissues reveals substantial levels of Shh signaling in normal, hyperplas...
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Introduction: Several reports have highlighted the role of Hh pathway activation in prostatecancer growth, but the relative contributions of autocrine and paracrine signaling remain unclear.Divergent reports of the presence or absence of autocrine signaling in established human prostatecancer cell lines has not clarified the matter.Materials and Methods: We comprehensively c...
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By breeding TRAMP mice with S100A9 knock-out (S100A9(-/-)) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression. CD11b(+) S100A9 expressing cells were not observed in normal prostate tissue from control C57BL/6 mice but were readily detected in TRAMP prostate tumors. Also, S100A9 expression was observed in association wi...
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Hyaluronan (HA), a high molecular weight glycosaminoglycan in the extracellular matrix, has been implicated in the promotion of malignant phenotypes, including tumor angiogenesis. However, little is known about the effect of HA on tumor-associated lymphangiogenesis. In this study, mouse hepatocellular carcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mi...
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Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...
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ژورنال
عنوان ژورنال: Journal of Dermatological Science
سال: 2018
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2018.02.010